Abstract
Synthesis of M2L2-type dinuclear metallacyclophanes [M(CO)3Br(μ-L)]2 (1 and 2, M = Mn; 3 and 4, M = Re) has been accomplished using semi-rigid ester functionalized pyridine ligands with organic spacers and metal precursor containing fac-M(CO)3 corners. The dinuclear metallacyclophanes were synthesized by the reaction of M(CO)5Br (M = Mn, Re) and ditopic pyridine ligands (L) (L = 1,2-phenylene diisonicotinate (pdi) and bis(4-(4-pyridylcarboxyl)phenyl)dimethylmethane (bpcpd)) under facile reaction conditions. The self-assembled compounds 1–4 were characterized by elemental analysis, IR, NMR, UV–Vis absorption and emission spectroscopic techniques. Compounds 1 and 3 were structurally characterized and the molecular masses of 2 and 4 were evaluated by ESI-MS. The anticancer activities of compounds 1–4 were investigated by in vitro cytotoxicity studies against different cancer cell lines as well as on normal cells and MTT assays. Compounds 2 and 4 showed broad-spectrum inhibitory activities on cancer cells in comparison with a reference compound (cisplatin) upon irradiation at λmax 365 nm. The UV–Visible absorption spectroscopy-based myoglobin assay further supported the nature of compound 2 as a photolabile CO releasing molecule (PhotoCORM).
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