Abstract
New bioconjugated amphiphilic mesogens with recognition groups have been synthesized, and their self-assembly behavior has been characterized at aqueous–liquid crystal (LC) interfaces. Specifically, the rod-shaped 2,3-difluoro-4′-(4-trans-pentylcyclohexyl)biphenyl-based mesogen was conjugated with either biotin or the arginine–glycine–aspartic acid (RGD) peptide sequence through a tetraethylene glycol chain. Langmuir film measurements revealed that the two biorecognition moieties lead to very different surface pressure–area isotherms, indicating that biotin and RGD have distinct effects on self-assembled monolayers formed by these bioconjugated mesogens at aqueous surfaces. Measurements of the surface-induced orientations of LCs exhibited by biotin-conjugated mesogens mixed with the room-temperature nematic LC 4-cyano-4′-pentylbiphenyl (5CB) revealed formation of cholesteric phases (consistent with the chiral nature of biotin) and evidence of the presence of the conjugated mesogen at aqueous interfaces. P...
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