Abstract
High efficiency photosensitizers for corneal neovascularization therapy are of importance because of their great advantages such as little adverse side effect and selective treatment. However, to develop high performance photosensitizer to cure the corneal disease remain challenging. In this work, a novel amphiphilic boron dipyrromethene (BODIPY) derivative (BDPY) was synthesized and it could self-assembly into nanoparticles in aqueous solution. These BDPY nanoparticles exhibited good photodynamic therapy effect on the corneal angiogenesis. The extended conjugation structure of BDPY lead to red-shift absorption and generated singlet oxygen upon red light irradiation. Our work might provide an interesting and valuable platform to design novel medicines for the new vessels of corneal therapy application.
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