Abstract
Molecular ordering through self-assembling of organic stationary phase is very useful for increasing selectivity in high-performance liquid chromatography (HPLC). Herein, we introduce comb-shaped polymers as self-assembled organic stationary phase for HPLC so that the selectivity can be robustly enhanced by increasing polymer chain rigidity as well as grafting density. For example, comb-shaped poly(octadecyl acrylate)-grafted silica (prepared by grafting-to and grafting-from methods) columns showed very high selectivity toward polycyclic aromatic hydrocarbon (PAH) solutes with regard to grafting technique onto silica. A comparison of the results obtained with synthetic columns and with commercial octadecylsilylated silica (ODS) revealed the effectiveness of tailor-made columns. Potential application of polypeptide lipid-grafted type stationary phases for molecular recognition has also been described.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
