Abstract
Three nanostructured photosensitizers with aggregation-induced emission (AIE) characteristics based on 2,3-bis(4ʹ-(diphenylamino)-[1,1ʹ-biphenyl]-4-yl) fumaronitrile (BDBF) were prepared for image-guided photodynamic therapy (PDT). BDBF was encapsulated with Pluronic F-127 (F127) to form usual spherical nanoparticles (F127@BDBF NPs) with a red fluorescence emission and 9.8% fluorescence quantum yield (FQY). Moreover, BDBF self-assembled into nanorods (BDBF NRs) in water. Compared with F127@BDBF NPs, BDBF NRs exhibited stronger orange fluorescence with a higher FQY of 23.3% and similar singlet oxygen (1O2) generation capability. BDBF NRs were further modified with F127 to form BDBF@F127 NRs with the same 1O2 generation ability as BDBF NRs. The three nanostructures exhibited a higher 1O2 production capacity than BDBF molecule in dissolved state and favorable stability in an aqueous solution as well as under physiological condition. In vitro photocytotoxicity experiments indicated that the three nanostructures inhibited tumor cell proliferation effectively. Therefore, to construct eligible nanostructures with a high FQY and 1O2 generation ability, simple self-assembly can serve as a valuable method to prepare photosensitizers with enhanced PDT.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
