Abstract
A major problem in designing adequate feedback controllers for physiological systems is the large variability in the dynamics of individuals. Adaptive control schemes are considered to be suitable candidates to solve this clinical problem and in this work the control of muscle relaxation using a self-tuning PID control technique is investigated. The performance of this control strategy is evaluated in a real-time simulation environment using published pharmacokinetics and pharmacodynamics of the recently introduced competitive neuromuscular blocking agent Atracurium. The sensitivity of the control algorithm with respect to simulated inter-individual variability in the dynamics is studied and the feasibility of combining bolus dose and closed-looD infusion protocols of Atracurium administration is demonstrated. A series of clinical trials was undertaken where the self-tuning PID algorithm successfully controlled the delivery of Atracurium to patients undergoing surgery.
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