Abstract
BackgroundMitral regurgitation (MR) is the most common valve lesion worldwide. However, the quantitative assessment of MR severity based on current guidelines is challenging and time-consuming; strict adherence to applying these guidelines is therefore relatively infrequent. We aimed to develop an automatic, reliable and reproducible artificial intelligence (AI) diagnostic system to assist physicians in grading MR severity based on color video Doppler echocardiography via a self-supervised learning (SSL) algorithm.MethodsWe constructed a retrospective cohort of 2,766 consecutive echocardiographic studies of patients with MR diagnosed based on clinical criteria from two hospitals in China. One hundred and forty-eight studies with reference standards were selected in the main analysis and also served as the test set for the AI segmentation model. Five hundred and ninety-two and 148 studies were selected with stratified random sampling as the training and validation datasets, respectively. The self-supervised algorithm captures features and segments the MR jet and left atrium (LA) area, and the output is used to assist physicians in MR severity grading. The diagnostic performance of physicians without and with the support from AI was estimated and compared.ResultsThe performance of SSL algorithm yielded 89.2% and 85.3% average segmentation dice similarity coefficient (DICE) on the validation and test datasets, which achieved 6.2% and 8.1% improvement compared to Residual U-shape Network (ResNet-UNet), respectively. When physicians were provided the output of algorithm for grading MR severity, the sensitivity increased from 77.0% (95% CI: 70.9–82.1%) to 86.7% (95% CI: 80.3–91.2%) and the specificity was largely unchanged: 91.5% (95% CI: 87.8–94.1%) vs. 90.5% (95% CI: 86.7–93.2%).ConclusionsThis study provides a new, practical, accurate, plug-and-play AI-assisted approach for assisting physicians in MR severity grading that can be easily implemented in clinical practice.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.