Abstract
BackgroundSleep duration affects health in various ways. The objective of the present study was to investigate the relationships among sleep duration, daytime napping and kidney function in a middle-aged apparently healthy Chinese population.MethodsAccording to self-reported total sleep and daytime napping durations, 33,850 participants who were 38–90 years old and recruited from eight regional centers were divided into subgroups. Height, weight, waist circumference, hip circumference, blood pressure, biochemical indexes, fasting blood glucose (FBG), postprandial blood glucose (PBG), HbA1c, creatinine and urinary albumin-creatinine ratio (UACR) were measured and recorded for each subject. Microalbuminuria was defined as UACR ≥30 mg/g, chronic kidney disease (CKD) was defined as eGFR <60 ml/min, and hyperfiltration was defined as eGFR ≥135 ml/min. Multiple logistic regression was applied to investigate the association between sleep and kidney function.ResultsCompared to sleeping for 7–8 h/day, the ORs for microalbuminuria for sleeping for >9 h/day, 8–9 h/day 6–7 h/day and <6 h/day were 1.343 (1.228–1.470, P<0.001), 1.223 (1.134–1.320, P<0.001), 1.130 (1.003–1.273, P = 0.045) and 1.140 (0.908–1.431, P = 0.259), respectively. The eGFR levels exhibited a U-shaped association with sleep duration among subjects with an eGFR ≥90 ml/min and an N-shaped association with sleep duration among subjects with an eGFR <90 ml/min. The OR for hyperfiltration for >9 h/day of sleep was 1.400 (1.123–1.745, P = 0.003) among participants with an eGFR ≥90 ml/min. Daytime napping had a negative effect on renal health. Compared to the absence of a napping habit, the ORs for microalbuminuria for 0–1 h/day, 1–1.5 h/day and >1.5 h/day of daytime napping were 1.552 (1.444–1.668, P<0.001), 1.301 (1.135–1.491, P<0.001) and 1.567 (1.353–1.814, P<0.001), respectively.ConclusionThe association of total sleep duration with renal health outcomes is U-shaped. Daytime napping has a negative effect on renal health.
Highlights
In recent decades, accumulating evidence has indicated that chronic sleep disorders represent a risk factor that affects metabolic health
The Estimated GFR (eGFR) levels exhibited a U-shaped association with sleep duration among
Both extremely short [11, 12] and long [13] sleep durations and poor sleep quality [14, 15] have been reported to be correlated with a higher urine albumin-to-creatinine ratio (UACR), which is a sensitive indicator for microalbuminuria or early-stage kidney damage, in a US and Japanese population
Summary
In recent decades, accumulating evidence has indicated that chronic sleep disorders represent a risk factor that affects metabolic health. Both cross-sectional and cohort studies have reported that inappropriate sleep durations contribute to glomerular hyperfiltration [13, 15, 27, 28] This difference in outcomes can be attributed to the differences in the race, age, social work stress, and health and economic status of the participants and to the fact that during the progression of CKD, healthy individuals tend to initially have glomerular hyperfiltration, followed by increased risk for renal injury, leading to a decrease in filtration rate and an accelerated development of CKD [29,30,31,32]. The objective of the present study was to investigate the relationships among sleep duration, daytime napping and kidney function in a middle-aged apparently healthy Chinese population
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
