Abstract
Intensity-based optical fiber sensors are one of the most studied sensor approaches thanks to their simplicity and low cost. Nevertheless, their main issue is their lack of robustness since any light source fluctuation, or unexpected optical setup variation is directly transferred to the output signal, which, significantly reduces their reliability. In this work, a simple and robust hydrogen peroxide (H2O2) optical fiber sensor is proposed based on the Localized Surface Plasmon Resonance (LSPR) sensitivity of silver and gold metallic nanoparticles. The precise and robust detection of H2O2 concentrations in the ppm range is very interesting for the scientific community, as it is a pathological precursor in a wide variety of damage mechanisms where its presence can be used to diagnose important diseases such as Parkinson’s disease, diabetes, asthma, or even Alzheimer’s disease). In this work, the sensing principle is based the oxidation of the silver nanoparticles due the action of the hydrogen peroxide, and consequently the reduction of the efficiency of the plasmonic coupling. At the same time, gold nanoparticles show a high chemical stability, and therefore provide a stable LSPR absorption band. This provides a stable real-time reference that can be extracted from the spectral response of the optical fiber sensor, giving a reliable reading of the hydrogen peroxide concentration.
Highlights
The use of optical fiber sensors has attractive and significant advantages such as being light-weight, a small size, biocompatibility, a remote sensing capability, immunity to electromagnetic interferences, and the possibility of multiplexing several signals [1]
We propose to use the LbL nano-assembly as a tool that allows the immobilization of different types of metallic nanoparticles such as Ag nanoparticles (AgNP) and AuNPs into the same multilayer polyelectrolyte structure
In order to determine the selectivity of the optical fiber sensor, the sensitive region has been exposed to ultrapure water and Hanks’ Balanced Salt Solution (HBSS), which was modified with calcium and magnesium, showed a pH range of 7.0–7.4, and was suitable for cell culture
Summary
The use of optical fiber sensors has attractive and significant advantages such as being light-weight, a small size, biocompatibility, a remote sensing capability, immunity to electromagnetic interferences, and the possibility of multiplexing several signals [1]. Optical fiber sensors have been studied in biomedical, clinical, environmental protection, healthcare and pharmaceutical research areas, among others [2]. In this sense, the development of precise and reliable optical fiber sensors for the analytical determination of hydrogen peroxide (H2 O2 ) is of great interest in the biosensing field because hydrogen peroxide is a highly reactive oxidant which plays an important role in many biological, chemical, environmental, or even industrial processes. The stability of the measurement conditions is a critical issue in most of the intensity-based optical fiber sensor approaches
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