Self-organized Cell Assembly Sequences in the Hippocampus

Abstract

Event Abstract Back to Event Self-organized Cell Assembly Sequences in the Hippocampus György Buzsáki1* 1 The State University of New Jersey, United States Cognitive operations, such as planning, free recall and problem solving, are assumed to depend on the brain’s self-organized cell assembly sequences, which allow the cognitive content to move forward or back in time. For example, it has been conjectured that recall of episodic memory is based on a mechanism that can link neuronal assemblies into temporal “phase sequences”), and that repeated recalls of the same memories arise from the evolution of similar cell assembly sequences in proper temporal order. I will present data, which demonstrate that perpetually changing cell assemblies in the rat hippocampus can occur not only during spatial navigation but also in the absence of changing environmental or body-derived inputs. During the delay period of a memory task each moment in time is dominated by the activity of a unique constellation of neurons, forming a self-organized sequence. Identical initiating conditions trigger a similar assembly sequence each time, whereas different conditions give rise to uniquely different sequences. The assembly sequences of hippocampal neurons correctly predict behavioral outcome, including errors. I hypothesize that neuronal algorithms, evolved for coding distance metric in spatial navigation, can also support recall and planning of action sequences. Similar assembly sequences may also underlie route planning in the prefrontal cortex. Conference: 10th International Conference on Cognitive Neuroscience, Bodrum, Turkey, 1 Sep - 5 Sep, 2008. Presentation Type: Oral Presentation Topic: Keynote Lectures Citation: Buzsáki G (2008). Self-organized Cell Assembly Sequences in the Hippocampus. Conference Abstract: 10th International Conference on Cognitive Neuroscience. doi: 10.3389/conf.neuro.09.2009.01.005 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Nov 2008; Published Online: 26 Nov 2008. * Correspondence: György Buzsáki, The State University of New Jersey, New Jersey, United States, buzsaki@andromeda.rutgers.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers György Buzsáki Google György Buzsáki Google Scholar György Buzsáki PubMed György Buzsáki Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.