Abstract
The aim of the present study is development and characterization of SNEDDS to enhance the bioavailability of anti-hyperlipidemic agent Atorvastatin calcium. The solubility was estimated in various solvent to find maximum solubility of drug in solvent. Vegetable oil (as vehicle), non-ionic surfactant (as surfactant, co-surfactant) and water is used to construct pseudo-ternary phase diagram (identify nanoemulsifying region). Stability, dispersibility and robustness to dilution to be performed for optimize formulations using phase diagram. Different formulations are prepared with various composition of vegetable oil, non-ionic surfactant. At one globule size of optimized system is expected to accept nano emulsion size range for improving the dissolution of Atorvastatin calcium. There by we may enhance the bio-availability of Atorvastatin.
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