Self-microemulsifying oral fast dissolving films of vitamin D3 for infants: Preparation and characterization.

Min Zhang,Ping Han,Ying Zou,Kehai Liu,Tingrui Zhang

doi:10.1002/fsn3.1108

Abstract

Combining the advantages of self‐microemulsifying technology and oral fast dissolving technology, a self‐microemulsifying oral fast dissolving films (SMEOFDF) of vitamin D3 was developed in this study. The pseudoternary phase diagram of microemulsion was constructed using water titration method, and the formulation of films was optimized by orthogonal experimental design. The prepared SMEOFDF of vitamin D3 was a thin film, in which the liquid drops of self‐microemulsion were embedded. It had good mechanical properties (thickness 166.7 ± 3.30 µm, tensile strength 38.45 ± 3.72 MPa, elongation 23.38 ± 4.23%, and folding endurance >200 times), and its disintegration time was about 18 ± 1.23 s. After being redissolved in water, microemulsion could form spontaneously, with particle size of 181.2 nm and zeta potential of 16.1 mV. The release profile of vitamin D from SMEOFDF could be well described by first‐order equation.

Highlights

Infants and young children are at high risk of micronutrient deficiency, and nutritional supplements play a vital role in safeguarding growth and promoting health
A food‐grade microemulsion was presented on the pseudoternary phase diagram (Figure 1), consisted of vitamin D3 as oil phase, Tween‐80 as surfactant, lauric acid as cosurfactant, and water as aqueous phase
In the pseudoternary phase diagram, the left area along the curve referred to turbid region, while the right was ME region

Summary

Introduction

Infants and young children are at high risk of micronutrient deficiency, and nutritional supplements play a vital role in safeguarding growth and promoting health. KEYWORDS infant, oral fast dissolving films, release kinetics, self‐microemulsifying, vitamin D Based on the above analysis, the above two problems can be solved by making nutrition supplements for infants and young children into the self‐microemulsifying oral fast dissolving films (SMEOFDF).

Results

Conclusion