Abstract
BackgroundThe association between COVID-19 infection and the development of autoimmune diseases is currently unknown, but there are already reports presenting induction of different autoantibodies by SARS-CoV-2 infection. Kikuchi-Fuimoto disease (KFD) as a form of histiocytic necrotizing lymphadenitis of unknown origin.ObjectiveHere we present a rare case of KFD with heart involvement after COVID-19 infection. To our best knowledge only a few cases of COVID-19-associated KFD were published so far. Based on presented case, we summarize the clinical course of KFD and its association with autoimmune diseases, as well we discuss the potential causes of perimyocarditis in this case.MethodsWe reviewed the literature regarding cases of “Kikuchi-Fujimoto disease (KFD)” and “COVID-19” and then “KFD” and “heart” or “myocarditis” by searching medical journal databases written in English in PubMed and Google Scholar.ResultsOnly two cases of KFD after COVID infection have been described so far.ConclusionSARS-CoV-2 infection can also be a new, potential causative agent of developing KFD.
Highlights
The clinical course of SARS-CoV-2 infection is highly variable and data about new complications associated with this virus are presented every pandemic day
A few principal mechanisms that may contribute to the development of autoimmunity after COVID-19 infection have proposed: the ability of SARS-CoV-2 to hyper-stimulate the immune system, induction of excessive neutrophil extracellular traps formation with neutrophil-associated cytokine responses and the molecular resemblance between self-components of the host and the virus [1, 2]
We summarize the clinical course of KikuchiFuimoto disease (KFD) and its association with autoimmune diseases, as well we discuss the potential causes of perimyocarditis in this case
Summary
The clinical course of SARS-CoV-2 infection is highly variable and data about new complications associated with this virus are presented every pandemic day. The association between COVID-19 infection and the development of autoimmune diseases has been presented by different authors. The association between COVID-19 infection and the development of autoimmune diseases is currently unknown, but there are already reports presenting induction of different autoantibodies by SARS-CoV-2 infection. We summarize the clinical course of KFD and its association with autoimmune diseases, as well we discuss the potential causes of perimyocarditis in this case. Results Only two cases of KFD after COVID infection have been described so far. Conclusion SARS-CoV-2 infection can be a new, potential causative agent of developing KFD
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
