Abstract
Poly(γ-glutamic acid) (γ-PGA) was chemically modified with dopamine (DA) to introduce catechol groups. The γ-PGA/DA conjugate was then simply mixed with cationic chitooligosaccharide (CHI-O) to induce gelation through intermolecular π-cation and ionic interactions. The gelation characteristics of the γ-PGA/DA/CHI-O mixtures were investigated according to the polymer concentration and CHI-O mixing ratio. The physically crosslinked γ-PGA/DA/CHI-O hydrogels exhibited excellent self-healing properties and injectability. In addition, the hydrogels showed an adhesive strength of >3 kPa on an egg membrane and >9 kPa on a glass slide. Therefore, the γ-PGA/DA/CHI-O hydrogels have great prospects as self-healing and tissue adhesive biomaterials.
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