Abstract
The conventional glutaraldehyde (GA) fixation for cardiac xenograft causes dystrophic calcification, and there is also a significant immune reaction to the galactose-α-1,3 galactose β-1,4-N-acetylglucosamine (α-Gal), leading to calcification. So, future investigation should be redirected in the quest for the αGal-free long-lasting substitutes.
Highlights
Background/Introduction The conventional glutaraldehyde (GA) fixation for cardiac xenograft causes dystrophic calcification, and there is a significant immune reaction to the galactose-a-1,3 galactose b-1,4-N-acetylglucosamine (a-Gal), leading to calcification
Self-expandable stented valve with glutaraldehydefixed cardiac xenograft treated by novel anticalcification protocols including immunologic modification for perventricular pulmonic valve implantation
Porcine cardiac xenografts were treated by decellularization, immunologic modification with alpha-galactosidase, space filler, GA fixation in organic solvent, and detoxification
Summary
Background/Introduction The conventional glutaraldehyde (GA) fixation for cardiac xenograft causes dystrophic calcification, and there is a significant immune reaction to the galactose-a-1,3 galactose b-1,4-N-acetylglucosamine (a-Gal), leading to calcification. Self-expandable stented valve with glutaraldehydefixed cardiac xenograft treated by novel anticalcification protocols including immunologic modification for perventricular pulmonic valve implantation Min-Seok Kim1, Saeromi Jeong1, Gi Beom Kim2, Hong-Gook Lim1*, Yong Jin Kim1 Future investigation should be redirected in the quest for the aGal-free long-lasting substitutes.
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