Abstract
with cytoxic and antimitotic activities. Presently it is used in the treatment of acute leukemia [ 1 ] . A considerable body of evidence has been accum- ulated which is in agreement with the existence of an intercalative complex with the DNA [2], which results in inhibition of both enzymatic RNA and DNA synthesis [3,4]. The study of the physico-chemical properties of the DNA-Daunorubicin complex [5] led us to a preliminary study of the behaviour of this molecule in solution. It could be expected that, due to its planar aromatic ring, strong interactions between molecules could exist as already shown for many compounds such as actinomycin [6], proflavine [7], purine derivatives [8-IO] or acridine orange [ 1 l] . This paper reports results of a study on the effects of the antibiotic concentration investigated by various physicochemical methods: ultraviolet and visible ab- sorption, circular dichroism (CD) and nuclear magnetic resonance (NMR). From the comparison between the results yielded by these different methods a model for the self-association of Daunorubicin is proposed.
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