Abstract
In this article, is reported for the first time the preparation of nanoparticles from graft copolymer composed of a hydrophilic backbone made of poly(2-methyl-2-oxazoline-co-2-pentyl-2-oxazoline) and hydrophobic poly(d,l-lactide) grafts. The copolymers were synthesized by the grafting-onto approach through the Huisgen 1,3-dipolar cycloaddition reaction. The success of the reaction was confirmed by 1H NMR, FTIR and thermogravimetric analysis (TGA). Different copolymers were prepared from two molecular weight backbones (5.7×103 and 14.2×103gmol−1) giving graft copolymers with molecular weight in the range of 3.7×104 to 11.3×104gmol−1. These copolymers self-assembled to form nanoparticles in water. Nanoparticles of spherical shape and various morphologies, going from polymersomes to core-shell and homogenous spherical nano-objects, were imaged by cryo-transmission electron microscopy (cryo-TEM) and analyzed by dynamic light scattering (DLS) and small-angle neutron scattering (SANS).
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