Abstract
The block copolymer poly (ε-caprolactone)-b-poly (N-isopropyl acrylamide) (PCL-b-PNIPAM) is synthesized via the combination of ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT). PCL-b-PNIPAM can self-assemble into the micelles taking PCL as the cores and PNIPAM as the shells. Add α-CD into the micelles, because the inclusion complexation of α-CD to PCL chains and phenols is stronger than that to PCL, to regulate the hydrophilic and hydrophobic features of PCL chain. So PCL-b-PNIPAM block copolymers have potential application in drug delivery and gene transfection.
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