Abstract
Hyaluronic acid, a biological macromolecule, was utilized as a drug for loading into niosomes. The ethanol injection method was used to formulate the niosomes using Cholesterol as the lipid and Span 80 as the non-ionic surfactant. HA-loaded niosomes showed a particle size of 177.6 nm and a % Entrapment Efficiency (%EE) of >95%. Drug release studies from the HA-loaded niosomes showed a controlled release profile for up to 4 days. Robust stability of the HA-loaded niosomes at both R.T (25–30 °C) and 4–8 °C was obtained. DPPH (2,2-diphenyl-1-picrylhydrazyl) antioxidant assay exhibited a greater enzyme inhibition than the free HA solution. In-vivo pharmacokinetic drug estimation parameters revealed a greater HA plasma concentration than free HA solution through the aerosol route. Moreover, organ biodistribution studies showed a greater localization of HA in lungs than in other organs.
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