Abstract
Single-drug therapy for cancer is greatly hampered by its poor water-solubility, difficulties in controlling and predicting the drug release that limited to the clinical application. In order to overcome these limitations, a novel self-assembled nanoparticle platform based on pectin-eight-arm-polyethylene glycol (8arm-PEG-COOH)-dihydroartemisinin (DHA) conjugate was first presented. Pet-8arm-PEG10K-DHA conjugate was synthesized by introducing hydrophobic drugs DHA to hydrophilic polymer Then, another anticancer drug hydroxycamptothecin (HCPT) was encapsulated into the self-assembled nanoparticles (PPDH NPs). The obtained nanoparticles possessed appropriate size (~ 84 nm), drug-loaded efficiency (~ 9.13 wt% DHA), encapsulation efficiency (~ 12.03 wt% HCPT), good stability and pH-dependent. The time-dependent cytotoxic of the PPDH NPs was only 4% 4T1 cell survived after 72 h. PPDH nanoparticle exhibited a higher cytotoxicity, longer blood retention time of free drug (8.0-fold DHA, 7.4-fold HCPT) and more ef...
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