Abstract
Lyotropic liquid crystals (LLCs) gel were prepared in aqueous solutions from sodium dodecyl and tetradecyl glycoside sulfate (APGS-Na) and the mixture of oleic acid with polyethylene glycol 400 (OP) to encapsulate retinol and octyl methoxycinnamate (OMC) as the medication delivery barrier. Complementary analysis like polarized optical microscopy (POM), small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), fourier transform infrared spectroscopy with attenuated total reflection (FTIR-ATR), and rheology were applied to characterize the LLCs gel. Additionally, the rate of retinol degradation in various retinol-loaded LLCs gel systems as well as the in vitro skin penetration and retention capabilities of OMC-loaded LLCs gel systems were assessed. According to the findings, the inner structure of the systems was lamellar (Lα) mesophase, which would be affected by the change of OP ratios. In addition, retinol-loaded LLCs gel decreased its degradation rate, while OMC-loaded sample presented the higher stratum corneum (SC) retention and lower epidermis and dermis (E + D) retention. Collectively, this study provides an effective way to prevent retinol from degradation as well as to control the release of OMC from LLCs.
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