Abstract
A number of selenoenzymes and selenoproteins have been identified. They are the glutathione peroxidase (GPX) family containing at least four different selenoenzymes, 1–4 the iodothyronine deiodinase family containing types I, II, and III deiodinases, 5–7 thioredoxin reductases 8, 9 and selenophosphate synthetase. 10 All of these selenoenzymes contain one selenium atom per polypeptide chain. Selenoproteins P and W (SeW) are the two most studied selenoproteins without a known function. Selenoprotein P is the only known selenoprotein that contains multiple selenocysteine residues, which is 10. 11 SeW is a low molecular weight protein originally reported as a missing component in selenium-deficient lambs suffering from white muscle disease. 12 Evidence has been presented for several other possible selenoproteins. 12a
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