Abstract
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein-encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP), SELENOT (selenoprotein T, SELT), SELENOV (selenoprotein V, SELV), and SELENOW (selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.
Highlights
This nomenclature applies to SELENOF, SELENOH, SELENOI, SELENOK, SELENOM, SELENON, SELENOO, SELENOP, SELENOS, SELENOT, SELENOV, and SELENOW
Resolving the Nomenclature of Selenoprotein Genes—Human gene designations are approved by the HUGO Gene Nomenclature Committee (HGNC), and genes in other mammals follow the same designations
Selenoproteins have traditionally been published using SEL or SEP symbols followed by a letter or a number
Summary
From the aDepartment of Medicine, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, the bBroad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, the cDepartment of Medical Biochemistry and Biophysics (MBB), Division of Biochemistry, Karolinska Institutet, SE-171 77, Stockholm, Sweden, the dDepartment of Cell and Molecular Biology, John A. Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, Peoples Republic of China, the ccDepartment of Biochemistry and Molecular Biology, Yeungnam University College of Medicine, Daegu 42415, South Korea, the ddCollege of Life Sciences and Biotechnology, Korea University, Seoul 02841, South Korea, the eeInstitute for Experimental Endocrinology, Charité-Universitaetsmedizin Berlin, D-13353 Berlin, Germany, the ffArchitecture et Réactivité de l’ARN, Université de Strasbourg, Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, France, the ggKSQ Therapeutics, Cambridge, Massachusetts 02139, the hhSchool of Biological Sciences, Seoul National University, Seoul 151-742, South Korea, the iiDepartment of Animal Science, Cornell University, Ithaca, New York 14853, the jjShenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Science, Shenzhen University, Shenzhen, 518060, Guangdong Province, Peoples Republic of China, the kkCentre National de la Recherche Scientifique, 75794 Paris, France, the llDepartment of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, the mmDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, the nnDepartment of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom, the ooDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, the ppCátedra de Inmunología, Facultad de Química, Instituto de Higiene, CP11600 Montevideo, Uruguay, the qqDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana 59717, the rrRheinische FriedrichWilhelms Universität Bonn, Institut für Biochemie und Molekularbiologie, 53115 Bonn, Germany, the ssDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, the ttDepartment of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, the uuDepartment of Biological Sciences, Towson University, Towson, Maryland 21252, and the vvDepartment of Environmental and Molecular Toxicology, College of Agricultural Sciences, Oregon State University, Corvallis, Oregon 97331
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