Abstract
Background/Aims. Selenium metabolism and polyamine biosynthesis are linked in their common requirement for Sadenosylmethionine. During the period of liver regeneration, many growth factors that affect kidney metabolism appear in circulation. The idea of the present study was to elucidate the influence of Se-Met on polyamine metabolism in renal tissue of hepatectomized rats.Methods: Male albino Wister rats, were used for this study. Partial hepatectomy was performed by the resection of two-thirds of liver tissue mass (67%). One group of hepatectomized animals received Se-Metionine intraperitoneally, in a single daily dose of 2.5 g per 100g body weight, and the other, as well as control group, received 0.9 NaCl instead of the drug for seven days. The last dose of selenomethionine was applicated on the 7 day after hepatectomy, one hour before sacrificing. Results: The supplementation of Se-methionine to hepatectomized animals causes the decrease of PAO activity in renal tissue. The amount of MDA follows PAO activity; it increases after operation in kidney tissue and decreases under SeMet treatment. Diamine oxidase activity increases under the influence of Se-methionine in renal tissue of hepatectomized rats. Conclusion: During regeneration, polyamine metabolism in renal tissue modifies. Se-methionine suplementation has a protective effect.
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