Selenium-containing nanosystems based on biocompatible polymer stabilizers: Kinetics, morphology, and thermodynamics

Abstract

Selenium-containing nanosystems based on biocompatible polymer stabilizers (PS) polyvinylpyrrolidone (Mw = (10–55) × 103) and poly-N,N,N,N-trimethylmethacryloyloxyethylammonium methyl sulfate (Mw = (30–13 000) × 103) are studied by means of light scattering and UV spectrophotometry in the range of the saturated adsorption capacity of selenium nanoparticles (ν = 0.1). Investigation of the self-organization of PS/Se0 nanosystems at ν = 0.1 shows that rate constant k* of nanostructure (NS) formation is determined by the nature of the PS, regardless of the polymer molecular weight (MW). Morphological and thermodynamic characteristics of selenium-containing NSes are determined, depending on the nature and MM of a PS. The formation of spherical polymolecular dense NSes is established.