Abstract
BackgroundThis study aimed to assess tendency of oxidative stress in COVID-19 patients depending on severity.MethodsThe study was conducted with 80 post-COVID-19 disease patients and 40 acutely ill patients. Content of selenium in blood plasma was detected by a fluorimetric method with di-amino-naphthalene using acidic hydrolysis. Selenoprotein P, malondialdehyde and 4-hydroxynonenal and their metabolite adducts were evaluated by spectrophotometric methods using commercial assay kits.ResultsObtained results showed that selenium content in blood for post-COVID-19 disease patients was of a similar lower norm for Latvian inhabitants. Selenium and seleno-protein P contents for acute patients were significantly decreased compared with post-COVID-19 disease patients.ConclusionIn conclusion, COVID-19 involves induction of antioxidant systems—in case of severe disease, patients have significantly low concentration of selenium, seleno-protein P and higher level of oxidative stress, which, in turn, confirms the more intense formation of free radicals in the body.
Highlights
SARS-CoV-2 is responsible for the COVID-19 pandemic that started in Wuhan, China, and has already claimed more than 4000 lives in Latvia.SARS-CoV-2 is a single-stranded RNA virus, such as Ebola virus, HIV, coxsackievirus, influenza, SARS, MERS (Zhang et al 2020)
Blood plasma Se, Sepp1, MDA and 4-HNE adduct status were evaluated from all patients samples
Patients were divided into three groups: infected with COVID-19 in the spring–early summer period (1st wave), summer–autumn patients (2nd wave), and acutely ill patients, with two subgroups: patients treated in the COVID19 unit and patients who were treated in the intensive care unit (20 + 20)
Summary
SARS-CoV-2 is responsible for the COVID-19 pandemic that started in Wuhan, China, and has already claimed more than 4000 lives in Latvia (inhabitants in Latvia on 01.01.2019: 1.908.000, number of COVID-19 cases: 291.000 on 10.01.2022).SARS-CoV-2 is a single-stranded RNA virus, such as Ebola virus, HIV, coxsackievirus, influenza, SARS, MERS (Zhang et al 2020). Studies of recent months show a close relationship between Se, Selenoprotein P (Sepp1) deficiency, oxidative stress level and COVID-19 disease incidence, severity and prognosis (Cheng and Prabhu 2019; Moghaddam et al 2020; Saito 2020; Zhang et al 2020). Se deficiency is thought to suppress the non-specific cell-mediated immune response and adaptive antibody response, which leads to dysregulation of the balanced host response. This increases the susceptibility to infections, with increased morbidity and mortality (Jayawardena et al 2020). Conclusion In conclusion, COVID-19 involves induction of antioxidant systems—in case of severe disease, patients have significantly low concentration of selenium, seleno-protein P and higher level of oxidative stress, which, in turn, confirms the more intense formation of free radicals in the body
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
