Abstract
The reactivity of nucleophilic selenium species toward nucleoside derivatives has been examined. A number of new 2'-deoxyribose nucleosides have been synthesized using this methodology. The cis elimination of the selenoxide obtained from the oxydation of the corresponding phenylselenide has been shown to be an efficient method for the preparation of the 2'-3'-unsaturated antiviral nucleoside 1-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine (D4T)
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