Abstract
The rise of antimicrobial resistance to antibiotics (AMR) as a healthcare crisis has led to a tremendous social and economic impact, whose damage poses a significant threat to future generations. Current treatments either are less effective or result in further acquired resistance. At the same time, several new antimicrobial discovery approaches are expensive, slow, and relatively poorly equipped for translation into the clinical world. Therefore, the use of nanomaterials is presented as a suitable solution. In particular, this review discusses selenium nanoparticles (SeNPs) as one of the most promising therapeutic agents based in the nanoscale to treat infections effectively. This work summarizes the latest advances in the synthesis of SeNPs and their progress as antimicrobial agents using traditional and biogenic approaches. While physiochemical methods produce consistent nanostructures, along with shortened processing procedures and potential for functionalization of designs, green or biogenic synthesis represents a quick, inexpensive, efficient, and eco-friendly approach with more promise for tunability and versatility. In the end, the clinical translation of SeNPs faces various obstacles, including uncertain in vivo safety profiles and mechanisms of action and unclear regulatory frameworks. Nonetheless, the promise possessed by these metalloid nanostructures, along with other nanoparticles in treating bacterial infections and slowing down the AMR crisis, are worth exploring.
Highlights
First,orthe traditional synthesis of selenium nanoparticles (SeNPs) is discussed, NPs drawbacks produced from its corresponding bulk material form, chemical platforms rely including those NPs by physiochemical methods, but stabilizing not limited to, on the reduction of Semade ions into the elemental form throughincluding, reducing and agents
The in vivo study was conducted on a rat diabetic wound infection model infected by Abbreviations: Polyvinyl acetate (PVA); ε-Poly-L-lysine (ε-PL); Sodium thiosulfate (Na2S2O3); L-ascorbic acid (C6H8O6); Bovine serum albumin (BSA); Carboxymethylcellulose (CMC); 3-Mercaptopropionic acid (HSCH2CH2CO2H); Methicillinresistant Staphylococcus aureus (MRSA); Methicillin-resistant Staphylococcus epidermitis (MRSE); Minimum inhibitory concentration (MIC); Growth culture (GC); Zone of inhibition (ZOI)
The findings suggest that quercetin and acetylcholine’s synergistic properties enhance the antibacterial activity of SeNPs [39]
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Decades later, lower respiratory infections were established as the fourth leading cause of death globally, among the prevalence of other bacterial pathologies [2] The reason behind this persistence was an accelerated rise of antimicrobial resistance to antibiotics, known as AMR. Evidence pointed to an increase in safety of the delivered molecules and effectiveness against microbial infections [14] Another type of NMs, metallic NPs (MNPs), has been widely investigated in laboratory settings due to their inherent antimicrobial properties related to the features of their metallic constituents [15]. Molecules 2021, 26, 3611 illness at an early stage and inducing inhibition of viral infections through targeted drug delivery [26] These attractive qualities incentivize researchers to apply SeNPs into the antimicrobial field, potentially presenting more effective treatments of current common. Molecules 2021, 26, x FOR PEER REVIEW and resistant bacteria strains, as well as other microbial pathogens, without the problems associated with more traditional NMs
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
