Selenium Deficiency is associated with inflammation and Cardio- metabolic dysregulation in women with Hypertensive disorders of Pregnancy

Abstract

Abstract Introduction/Objective Selenium (Se) deficiency has been speculated to enhance Oxidative inflammation in Pregnancy, leading to endothelial dysfunction, which has been implicated in the aetiopathogenesis of Hypertensive disorders of Pregnancy. This study aimed at evaluating the Selenium Status of pregnant women and its role in inflammation and cardio-metabolism in pregnant women with Hypertensive disorders of Pregnancy. Methods/Case Report The study involved 200 healthy women with Single Pregnancy who presented to Obstetrics and Gynaecology clinic of IMSUTH Teaching Hospital, Nigeria. These subjects were recruited between 10 to 15 weeks of gestation. 52 of the them who subsequently developed Hypertensive disorders ;Preeclampsia (PE)-15 and Pregnancy Induced Hypertension (PIH)- 37) were compared with their148 counterparts who remained Normotensive. The groups were matched for age, BMI, gestational age and parity. The blood Selenium levels were determined using Atomic Absorption spectrophotometer, while ELIZA was used for Markers of Inflammation and Cardio-metabolic risk (Hs Crp, Lipid profile, Insuline, MDA,TAC, GSH). P <0.05 was considered statistically significant for all variables. Results (if a Case Study enter NA) There was significant reduction in the mean levels of Selenium in Pregnant women with PE and PIH (52.41 μg/L, 56.02 μg/L) when compared with Normotensive (68.84 μg/L). Hs-CRP, LDL and MDA showed significant increase in the study groups (PE and PIH) against the Normotensive group (p=0.001, 0.004 and 0.001) respectively. A significant reduction was observed in the TAC and GSH in PE and PIH (p> 0.005).. There was also a significant increase in the Insulin levels of the PE group compared with the Control group. There was a negative correlation relationship between Selenium and Hs- CRP (r = -0.533, r=-601), serum lipids and Insulin and BMI in the study groups. Conclusion From our study, Selenium deficiency may be associated with Dyslipidemia, impaired Insulin Metabolism and may serve as a predictive Risk marker of Heart disease in women with Hypertensive disorders of Pregnancy.