Abstract
In 30 healthy persons (control), 17 renal cell carcinoma (RCC) patients, 30 hemodialysis patients (HD) and 15 healthy persons in the Takko town (Aomori prefecture), the selenium concentration in serum was determined by PIXE. The mean serum selenium concentration in healthy controls was 1.4 ± 0.6 μ mol/l , in RCC patients 1.1 ± 0.4 μ mol/l , in HD patients 1.3 ± 0.9 μ mol/l and in healthy persons in the Takko town 1.7 ± 0.7 μ mol/l . There was a significant statistical difference between RCC patients and healthy persons in the Takko town ( p < 0.05). Takko town is famous for the production of garlic. Epidemiological studies have established an inverse relationship between garlic consumption and incidence of gastric, colon, and laryngeal cancers. Garlic is a rich source of selenium in the food. Contents of selenium in normal and carcinoma fractions in kidneys of RCC patients were determined by PIXE. The results indicate that RCC patients caused significant decrease of selenium contents in the carcinoma fraction ( p < 0.05).
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