Selenium as a 'nutraceutical': how to conciliate physiological and supra-nutritional effects for an essential trace element.

Abstract

To review how selenium has been appreciated in nutrition and therapeutics for the last few decades. Selenium is a powerful micronutrient constituting the active centre of about 20 eukaryotic proteins highly relevant in biochemistry, mostly for redox state-regulating properties. This element is now better recognized as a biologically important nutrient. Insufficient dietary intake for satisfying biological requirements in several physiological or pathological conditions has been demonstrated, and it is now established that inadequate intake has adverse consequences for disease susceptibility and the maintenance of optimal health. The 'recommended dietary allowances' for selenium actually seem inadequately defined considering not only the recent evolutions of selenium biochemistry, but also the way in which selenium requirements are estimated. Indeed, the element also seems active at supra-nutritional levels of dietary intake, mostly in the field of cancer prevention, and maybe also at pharmacological levels as an adjuvant treatment of some cancers. Selenium perfectly illustrates the concept of 'nutraceutical' and the need for changing paradigms in nutrition. Indeed, intakes for satisfying physiological needs as reflected by classical selenium-dependent biochemical functions (mostly glutathione peroxidase activity) only explain a part of selenium biological potency. Other beneficial effects can be obtained at higher nutritional intakes, which in turn implies specified chemical forms and doses. Studies are under way to document these effects in a more complete and convincing manner.