Abstract
The microsomal share of liver homogenate 75Se after injection of a tracer dose of 75SeO 3 2− was three times greater in rats fed a selenium-deficient diet than in rats fed a selenium-adequate diet. Basal levels of microsomal cytochromes P-450 and b 5 were unaffected by selenium deficiency. However, induction of these cytochromes by phenobarbital was markedly inpaired in selenium-deficient rats, whereas liver weight increase and NADPH cytochrome c reductase induction were not impaired. These data indicate that selenium is essential for phenobarbital induction of microsomal hemoproteins.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and biophysical research communications
Paper Title
Journal
Date
