Selenite-Induced Cataract as a Model for Cataract Diseases: Limitations, Considerations, and Alternative Approaches

Abstract

Cataract diseases, characterized by the opacification of the lens, pose a significant global health burden. Animal models are invaluable for understanding cataractogenesis and testing potential treatments [1]. The selenite-induced cataract model has been widely used due to its rapid onset and predictable progression. However, this model has limitations that must be considered. This article reviews the limitations of the selenite-induced cataract model and explores alternative approaches that better represent the complexity and natural course of human cataract diseases [2].