Abstract
Whole-cell perforated patch clamp recordings were used to analyze selectivity of ω-CgTx-MVIIC toxin for voltage-dependent calcium currents in cultured myenteric neurons from guinea-pig small intestine. ω-CgTx-MVIIC (300 nM) blocked 37 ± 9% of the peak current activated from −80 mV in 15 neurons by mostly affecting the plateau phase of the current. The toxin suppressed peak current activated from −30 mV dose-dependently with an ICso of 70 ± 8 nM. The blockade was complete at toxin concentrations of 1 μM. Thus, it appears that ω-CgTx-MVIIC blocks high voltage activated (HVA) calcium channels in the myenteric neurons unselectively as well as other types of HVA Ca 2+ channels including P and Q channels.
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