Abstract
Speech Direct C–H bond functionalizations are highly attractive tools for an overall streamlining of organic chemistry, since these methods avoid the preparation and use of prefunctionalized starting materials. We have introduced carboxylates as catalytic additives for site-selective direct arylations and alkylations employing versatile ruthenium complexes, which were found to display complementary chemoand site-selectivities as compared to palladium(0)or copper(I) catalysts. Detailed mechanistic insight into the working mode of the working mode of the C–H bond ruthenation step set the stage for the development of rutheniumcatalyzed twofold C–H bond functionalizations as well as step-economical oxidative annulations of alkynes. These oxidative C–H bond functionalizations could be performed in an aerobic fashion with ambient air as the terminal oxidant, and provided atomand step-economical access to various important bioactive heterocycles.
Highlights
We have introduced carboxylates as catalytic additives for site-selective direct arylations and alkylations employing versatile ruthenium complexes,[2] which were found to display complementary chemo- and site-selectivities as compared to palladium(0)- or copper(I) catalysts.[3]
Detailed mechanistic insight into the working mode of the working mode of the C–H bond ruthenation step set the stage for the development of rutheniumcatalyzed twofold C–H bond functionalizations as well as step-economical oxidative annulations of alkynes.[4]
These oxidative C–H bond functionalizations could be performed in an aerobic fashion with ambient air as the terminal oxidant,[5] and provided atom- and step-economical access to various important bioactive heterocycles.[6]
Summary
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