Abstract
1. 1. Transferrins of natricine snakes from four Zoogeographie regions were compared using quantitative microcomplement fixation. 2. 2. The magnitude of differences in transferrins of two species correlates better with their length of reproductive isolation than with their external morphology or ecology. 3. 3. Data suggest that the evolutionary lines leading to modern Asiatic natricine genera originated during the Miocene. 4. 4. By the end of the Miocene groups classified as Natrix had become isolated on four continents. 5. 5. Natrix has undergone extensive speciation in North America since the Miocene. The majority of structural changes in the transferrins of the resulting species seem to have been nonadaptive.
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