Abstract
Platelet-activating factor (PAF) is a phospholipid autacoid inducing peripheral vasodilation and vascular leak, both pathophysiological hallmarks of sepsis-induced cardiovascular dysfunction resulting in hypotension [1]. Indeed, PAF has been implicated in various animal models of sepsis and in septic humans [2]. A deficiency in the vasopressor hormone arginine vasopressin (AVP), a mixed V1a/V2 receptor agonist, also contributes to the cardiovascular dysfunction of septic shock, leading to clinical use of AVP for this condition [3,4]. These various findings led us to hypothesize that the selective V1a receptor agonist FE 202158 would be effective in a rat model of PAF-induced hypotension.
Highlights
The aim of this study was to elucidate the impact of ICU-acquired infection on ICU and hospital mortality
The goal from this study is to evaluate weaning predictor indexes in patients during weaning from mechanical ventilation (MV)
This study aims to evaluate the effects of the threshold in such situations
Summary
The aim of this study was to elucidate the impact of ICU-acquired infection on ICU and hospital mortality. Methods A total of 48 community patients (36 men, 11 women, age 50.17 ± 17.974 years, APACHE II score 13.51 ± 6.153) who were expected to stay in the ICU for >5 days were included in this study. Specific examples of feedback are as follows: ‘good update of management plan reinforces need for taking into account concurrent medication when resuscitating patients’, ‘nice simple messages with good starting points for trying to deal with these complicated patients’, ‘useful data on risk of recurrence as this is a question often asked by patients’ This feedback was encouraging as it showed how the primary care professionals planned to change their practice to improve patient outcomes as a result of the learning. The course was considered excellent by 63% of the participants and good by 36%
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