Abstract
Abstract Different (±)-4-(3/4-acetoxyaryl)-5-ethoxycarbonyl-6-methyl-3,4-dihydropyrimidin-2-ones have been synthesized and subjected to enantioselective deacetylation reactions mediated by different lipases in organic media. Novozyme 435 in tetrahydrofuran:diisopropyl ether was found to be the catalyst of choice for efficient enantioselective deacetylation of dihydropyrimidinones under study. Further, we discovered that lipase isolated from Pseudomonas aeruginosa can be used for selective acylation of secondary hydroxyl groups in nucleosides. This observation can be very useful for selective manipulation of different hydroxyl groups in nucleosides.
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