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Abstract
Tumor treating fields (TTFs) are a newly developed cancer therapy technology using an alternating electric field that may be a possible candidate for overcoming the limitations of conventional treatment methods currently used in cancer treatment. Although clinical results using TTFs appear promising, concerns regarding side effects must be clarified to demonstrate the effectiveness of this treatment method. To investigate the side effects of TTF treatment, the damage to normal cell lines and normal tissue of a mouse model was compared with the damage to tumor cells and tumors in a mouse model after TTF treatment. No serious damage was found in the normal cells and normal tissues of the mouse model, suggesting that the side effects of TTF treatment may not be serious. Our evidence based on in vitro and in vivo experiments suggests that TTF may cause selective damage to cancer cells, further demonstrating the potential of TTF as an attractive alternative to conventional cancer treatment modalities.
Highlights
Despite desperate efforts, cancer is among the most urgent public health problems worldwide, accounting for 1 of 6 deaths
To clarify the side effects of treating fields (TTFs) treatment, we investigated the damage to normal cell lines and normal tissue in a mouse model after TTF treatment
We examined the inhibitory effect of TTF treatment on cancer and normal cell proliferation using malignant melanoma cells
Summary
Cancer is among the most urgent public health problems worldwide, accounting for 1 of 6 deaths. A new cancer treatment technique (called tumor treating fields (TTFs)) using ‘alternating electric fields’ has been reported to result in an excellent therapeutic effect on glioblastoma multiform (GBM), which is among the refractory cancers treated using the aforementioned conventional therapies[1]. Previous studies suggested that TTFs, which involve an alternating electric field of low intensity and intermediate frequency, can suppress mitosis by interfering with the alignment of the spindle and lead to cell cycle arrest at the G2/M phase and cell death[1,5]. Clinical results have indicated that one of the most frequent side effects in patients treated with TTFs is local skin irritation mainly due to the need to attach
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