Abstract

Starting from C‐CF3‐substituted aldimines, trifluoromethyl β‐lactams were obtained as only products in the reaction with some α‐bromo esters in the presence of activated zinc dust. Different solvents, molar ratios, and temperature were tested to determine the best reaction conditions that led only to desired cyclic compounds. The influence of another ester group on the aldimine chain and the reaction diastereoselectivity were also considered.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.