Selective synthesis of functionalized α,β-multi-substituted α-amino cyclopentanones via an α-iminol rearrangement enabled by Pd-catalyzed addition of arylboronic acids to nitriles

Abstract

An efficient approach to construct α, β-multi-substituted α-amino cyclopentanones is described through an α-iminol rearrangement enabled by Pd-catalyzed addition of arylboronic acids to nitriles.