Selective synthesis of fluoroalkyl-containing multisubstituted benzenes through Co-mediated [2+2+2] cycloaddition reaction with fluoroalkylated alkynes

Abstract

Abstract The reaction of various fluoroalkylated alkynes with 1.2 equiv of Co 2 (CO) 8 in toluene at room temperature for 30 min took place smoothly to give the corresponding alkyne–cobalt complex quantitatively. Without its purification, treatment of the in situ -generated complex with 6.0 equiv of various nonfluorinated alkynes at 130 °C for 4 h provided monofluoroalkylated multisubstituted benzenes in moderate to good yields.