Abstract
An efficient method for selective, solid phase synthesis of unsymmetrical ureas and hydantoins from a common phenyl carbamate dipeptide intermediate is decribed. Reaction of phenyl carbamate 6 with primary or secondary amines (R3R4NH) in THF results in selective formation of ureas 8, whereas its treatment with a tertiary amine base (iPr2NEt or DBU) in DMF affords clean conversion to hydantoins 10.
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