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Abstract
An automated separation system is described for identifying the optimal conditions for purifying an amine from a mixture.
Highlights
We present a rapid continuous processing methodology to screen for the optimal, selective, liquid–liquid extraction conditions, from a typical post-reaction mixture of amines, using both inline and online analysis to systematically alter the pH, by controlling the acid addition pump
Acid/base mediated amine extraction has been demonstrated with these units, selective extraction, incorporating pH monitoring to control the removal of impurities, has not
The Zaiput has an optimal volume ratio of 1 : 1 and this was chosen to minimise the potential for loading, at a maximum flowrate of 2 mL min−1 and using a PTFE hydrophobic membrane (0.9 μm pore size)
Summary
We present a rapid continuous processing methodology to screen for the optimal, selective, liquid–liquid extraction conditions, from a typical post-reaction mixture of amines, using both inline and online analysis to systematically alter the pH, by controlling the acid addition pump. This produced an autonomous system for exploring the amine extraction conditions: optimal amount of acid and organic-aqueous phase ratio.
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