Abstract
Resistive pulse nanopore sensing has enabled the detection and characterization of a growing ensemble of water soluble peptides. The method relies on statistical analysis of short-lived (ca. 1 ms) current blockades, which yield distributions showing correlations between blockade depth and peptide size. Our efforts have focused on using tiopronin-capped gold nanoclusters, trapped in alpha hemolysin nanopores, to demonstrate peptide detection via ligand exchange. Earlier results showed that cluster structure fluctuations can be observed at the single nanocluster limit and these fluctuations are directly related to the size of the passivating ligands on the cluster surface.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
