Selective ruthenium-catalyzed double reductive aminations using hydrosilane to access tertiary amines and piperidine derivatives

Abstract

A highly selective double reductive aminations of aldehydes with anilines to give tertiary amines, in the presence of [RuCl2(p-cymene)]2 catalyst and PhSiH3, was performed under neat conditions. Piperidine derivatives were successfully synthesized by a double reductive amination followed by cyclisation from glutaric dialdehyde with anilines.