Abstract

SUMMARYSelective renal angiography was carried out in 9 patients with renal failure due to infection. Six patients had leptospirosis, two had E. coli septicemia and one had falciparum malaria. In all cases the pathological diagnosis was tubular necrosis. Evidence of cortical ischemia, characterized by distinct visualization of fine vascular distribution without veiling of the nephrographic effect, loss of the normal zone of corticomedullary distinction and poor maximum nephrographic density, was demonstrated in all cases. Proximal renal arterial constriction was shown in cases of septicemia, while in leptospirosis and malaria the proximal arterial trees appeared normal. These changes were reversible in 6 cases which were followed. In each case there was positive correlation between the creatinine clearance and nephrographic density.

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