Abstract
NORADRENALINE and acetylcholine synthesised de novo are released in preference to the endogenous store following nerve depolarisation. Kopin et al.1 showed that the specific activity of noradrenaline (14C-tyrosine precursor) released from cat spleen during sympathetic nerve stimulation is greater than that of the tissue store; however, 3H-noradrenaline which was just taken up by the nerve is released concomitantly with the endogenous store. In similar experiments, newly synthesised acetylcholine is selectively released from superior cervical ganglia2, phrenic nerve3, Torpedo electroplax4, and brain cortical slices5. We used rat cortical synaptosomes (pinched off nerve endings) to study the temporal relationships of GABA biosynthesis, uptake and release.
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