Abstract
[ 125I]Apamin binding sites were examined using quantitative autoradiography in the hippocampus of 9 patients with Alzheimer's disease and 8 age-matched controls. Within the hippocampal formation from control subjects, [ 125I]apamin binding sites were highly concentrated in the subiculum and CA1. In Alzheimer's disease there was a marked and discrete loss of [ 125I]apamin binding sites in the subiculum 4control= 1.10 ± 0.10pmol/g; Alzheimer= 0.71 ± 0.09pmol/g) and CA1 (control= 1.41 ± 0.09pmol/g; Alzheimer= 0.85 ± 0.11pmol/g; values are mean±S.E.M.). This reduction of [ 125I]apamin binding sites in the subiculum correlated with cell density but not neuritic plaque density. These results indicate that an anatomically discrete loss of Ca 2+-dependent K + channels within the hippocampal formation occurs in Alzheimer's disease.
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