Abstract
Gallic acid is widely used in the field of food and medicine due to its diversified bioactivities. The extraction method with higher specificity and efficiency is the key to separate and purify gallic acid from complex biological matrix. Herein, using self-made core-shell magnetic molecularly imprinted polymers (MMIP) with gallic acid as template, a hollow magnetic molecularly imprinted polymer (HMMIP) with double imprinting/adsorption surfaces was prepared by etching the mesoporous silica intermediate layer of MMIP. The characterization and adsorption research showed that the HMMIP had larger specific surface area, higher magnetic response strength and a more stable structure, and the selectivity and saturated adsorption capacity (2.815 mmol/g at 318 K) of gallic acid on HMMIP were better than those of MMIP. Thus, in addition to MMIP, the improved HMMIP had excellent separation and purification ability to selectively extract gallic acid from complex matrix with higher specificity and efficiency.
Highlights
Gallic acid is widely used in the field of food and medicine due to its diversified bioactivities
In order to prove that the desired functional groups were grafted onto the corresponding materials and to analyze the etching of Si elements, the Fe3 O4 nanoparticle, hollow magnetic molecularly imprinted polymer (HMMIP), and molecularly imprinted polymers (MMIP) were characterized by FT-IR
The HMMIP and MMIP were characterized by X-ray photoelectron spectroscopy (XPS) spectroscopy
Summary
Methacryloxy propyl trimethoxyl silane (MPS, 97.0%), 4-vinylpyridine (4-VP, 96.0%), ethylene glycol dimethacrylate (EGDMA, 98.0%), and 2,20 -azobis-isobutyronitrile (AIBN, 98.0%) were supplied by Shanghai McLean Biochemical Technology Co., Ltd. (Shanghai, China). Infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), a vibrating sample magnetometer (VSM), the Brunauer–Emmett–Teller specific surface area test method (BET), and thermogravimetry analysis (TGA) were used to characterize the structure of HMMIP and MMIP. TEM (JEOL JEM 2100, Tokyo, Japan) was used to observe the coating structure, diameter, and appearance. VSM (SQUID-VSM, San Diego, CA, USA), BET (Quadrasorb Si-3MP, Boynton Beach, FL, USA), and TGA 3 of 187300, To kyo, Japan) were used to investigate the magnetic intensity, specific surface area, and ther mal stability of hollow imprinted polymers before and after preparation, respectively. HPLC analysis was conducted on the Purkinje L600 HPLC system (Beijing, China) with a UV-Vis absorption detector
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